Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA
molecules that are assembled within major nuclear compartments called nucleoli,. Existing …

R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …

BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …

R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are
physiological structures that regulate various cellular processes occurring on chromatin …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …