▪ Abstract Alzheimer's disease (AD) is unique in medicine in that millions of people suffer
from what appears to be the same form of disease, and unlike most other late-onset …

For approximately 80 years following Alzheimer's description of the disease that bears his
name, a gulf divided researchers who believed that extracellular deposits of the amyloid β …

Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …

Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …

The Volga German kindreds are a group of seven related families with autosomal dominant
early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes …

Background The ε4 allele of apolipoprotein E has been associated with an increased risk of
late-onset Alzheimer's disease. In a cohort of elderly subjects we prospectively investigated …

Missense mutations in the presenilin 2 (PS-2) gene on chromosome 1 were sought by direct
nucleotide sequence analysis of the open reading frame of 60 pedigrees with familial …

Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …

The p-amyloid precursor protein (pAPP) gene of the mouse was disrupted by inserting into
exon 2 a cassette containing a neomycin resistance gene and a putative transcription …

Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …