Therapeutic options and drug delivery strategies for the prevention of intrauterine adhesions

L Kou, X Jiang, S Xiao, YZ Zhao, Q Yao… - Journal of Controlled …, 2020 - Elsevier
Intrauterine adhesions (IUAs) are bands of fibrous tissue that form in the endometrial cavity
and associated with the increased risk of abnormal menstruation, recurrent pregnancy loss …

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

X Hu, H Wu, X Yong, Y Wang, S Yang, D Fan… - MedComm, 2023 - Wiley Online Library
The endometrium is a unique human tissue with an extraordinary ability to undergo a
hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and …

Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model

M Neykhonji, F Asgharzadeh, M Farazestanian… - Scientific Reports, 2024 - nature.com
Intrauterine adhesion (IUA), also referred to as Asherman's syndrome, is characterized by
fibrosis, inflammation, and can cause amenorrhea and infertility due to abnormal …

Injectable, stable, and biodegradable hydrogel with platelet-rich plasma induced by l-serine and sodium alginate for effective treatment of intrauterine adhesions

X Xie, X Ao, R Xu, H Lv, S Tan, J Wu, L Zhao… - International Journal of …, 2024 - Elsevier
The combination of pharmacological and physical barrier therapy is a highly promising
strategy for treating intrauterine adhesions (IUAs), but there lacks a suitable scaffold that …

Effects and safety of hyaluronic acid gel on intrauterine adhesion and fertility after intrauterine surgery: a systematic review and meta-analysis with trial sequential …

Y Luo, Y Sun, B Huang, J Chen, B Xu, H Li - American Journal of Obstetrics …, 2024 - Elsevier
Objective This study aimed to determine the efficacy and safety of hyaluronic acid gel for the
prevention of intrauterine adhesions and improved fertility after intrauterine surgery. Data …

Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression

EAN Abdel-Razek, AM Abo-Youssef, AA Azouz - Life sciences, 2020 - Elsevier
Aim Despite the great efficacy reported for cisplatin as a widely used chemotherapeutic
agent, its clinical use is limited by the challenge of facing its serious side effect; …

[HTML][HTML] Inhibitory activity of flaxseed oil against CdCl2 induced liver and kidney damage: Histopathology, genotoxicity, and gene expression study

KA Diab, NE Ibrahim, MA Fahmy, EM Hassan… - Toxicology Reports, 2020 - Elsevier
The present work evaluated the effect of flaxseed oil (FO) against toxicity induced by
cadmium chloride (CdCl 2) in the mouse liver and kidney. Male Swiss albino mice were …

Benchmark dose and the adverse effects of exposure to pendimethalin at low dose in female rats

MF Gad, ATH Mossa, AA Refaie… - Basic & Clinical …, 2022 - Wiley Online Library
Pendimethalin (PND) is a dinitroaniline herbicide widely used to control broadleaf and
annual grasses. Although the acute oral toxicity of PND is> 5 g/kg b. wt. in humans (LD50 for …

Metabolomics and pharmacodynamic analysis reveal the therapeutic role of Prunella vulgaris oil on intrauterine adhesion rats

L Li, J Deng, L Lin, Y Li, Y Lin, B Xia, D Liao - Journal of Pharmaceutical …, 2022 - Elsevier
Metabolomics is applied to explore the curative effect of complex systems, such as Chinese
medicine. Intrauterine adhesion (IUA) harms the reproductive system and affects fertility, and …

Protective Role of ficus carica extract against hepato-testicular side effects and genotoxicity induced by cisplatin

MA Fahmy, EE Hassan, NE Ibrahim, EM Hassan… - Pharmacognosy …, 2020 - phcogj.com
Objective: The present work investigated the protective effect of Ficus carica (common fig)
leaves methanol extract against genotoxicity and testicular damage of cisplatin (CP) and …