Moving beyond the mousetrap: Current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and …
Y Agarwal, C Beatty, S Biradar, I Castronova, S Ho… - Retrovirology, 2020 - Springer
The development of safe and effective combination antiretroviral therapies for human
immunodeficiency virus (HIV) infection over the past several decades has significantly …
immunodeficiency virus (HIV) infection over the past several decades has significantly …
Advances in humanized mouse models to improve understanding of HIV-1 pathogenesis and immune responses
A Gillgrass, JM Wessels, JX Yang… - Frontiers in …, 2021 - frontiersin.org
Although antiretroviral therapy has transformed human immunodeficiency virus-type 1 (HIV-
1) from a deadly infection into a chronic disease, it does not clear the viral reservoir, leaving …
1) from a deadly infection into a chronic disease, it does not clear the viral reservoir, leaving …
Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission
CN Roy, ST Shu, C Kline, L Rigatti, TE Smithgall… - Scientific Reports, 2023 - nature.com
Humanized mice have been used to study human immunodeficiency virus type 1 (HIV-1)
transmission, pathogenesis, and treatment. The ability of pediatric thymus tissue implanted …
transmission, pathogenesis, and treatment. The ability of pediatric thymus tissue implanted …
Immunocompetent human 3D organ-specific hormone-responding vaginal mucosa model of HIV-1 infection
I Saba, C Barat, S Chabaud, N Reyjon… - … Engineering Part C …, 2021 - liebertpub.com
The lack of appropriate experimental models often limits our ability to investigate the
establishment of infections in specific tissues. To reproduce the structural and spatial …
establishment of infections in specific tissues. To reproduce the structural and spatial …
CG dinucleotide removal in bioluminescent and fluorescent reporters improves HIV-1 replication and reporter gene expression for dual imaging in humanized mice
CN Roy, MA Benitez Moreno, C Kline… - Journal of …, 2021 - Am Soc Microbiol
Visualizing the transmission and dissemination of human immunodeficiency virus type 1
(HIV-1) in real time in humanized mouse models is a robust tool to investigate viral …
(HIV-1) in real time in humanized mouse models is a robust tool to investigate viral …
Long‐acting and extended‐release implant and nanoformulations with a synergistic antiretroviral two‐drug combination controls HIV‐1 infection in a humanized …
The HIV pandemic has affected over 38 million people worldwide with close to 26 million
currently accessing antiretroviral therapy (ART). A major challenge in the long‐term …
currently accessing antiretroviral therapy (ART). A major challenge in the long‐term …
APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants
R Dwivedi, Y Wang, C Kline, DK Fischer… - Frontiers in …, 2022 - frontiersin.org
The V179I substitution in human immunodeficiency virus type 1 (HIV-1) reverse
transcriptase (RT) is selected in humans or mouse models treated with certain …
transcriptase (RT) is selected in humans or mouse models treated with certain …
[HTML][HTML] Pre-and Post-Exposure Prophylaxis in Sexually Transmitted Diseases: An Uncharted Territory
A Chakraborty - Indian Journal of Dermatology, 2024 - journals.lww.com
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Elucidating the roles of αβ and γδ T cells in HIV infection
S Biradar - 2021 - search.proquest.com
Untreated HIV infection leads to acquired immunodeficiency syndrome (AIDS) in nearly all
cases [1]. However, a small proportion of HIV-infected individuals, known as long-term non …
cases [1]. However, a small proportion of HIV-infected individuals, known as long-term non …
CG dinucleotide codon removal improves expression of HIV-1 reporter viruses in humanized mice
MAB Moreno - 2021 - search.proquest.com
Two replication-competent CCR5-tropic HIV-1 reporter constructs were developed that
encode either nanoluciferase (nLuc) or a near-infrared fluorescent protein (iRFP) for in vivo …
encode either nanoluciferase (nLuc) or a near-infrared fluorescent protein (iRFP) for in vivo …