Abstract HER2-positive (HER2+) breast cancer (BC) is a heterogenous and multifaceted
disease, with interesting therapeutic implications. First, all intrinsic molecular subtypes can …

Immunoediting represents a complex and dynamic process involving cancer and immune
system cells, composed by three intertwined phases: elimination, equilibrium and escape. A …

Background T follicular helper cells (Tfh) are essential to shape B cell response during
germinal center formation. Tfh accumulation has been reported in various human cancers …

Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show
that production of IL1β in primary breast cancer tumors is linked with advanced disease and …

Immune checkpoint therapy in breast cancer remains restricted to triple negative patients,
and long-term clinical benefit is rare. The primary aim of immune checkpoint blockade is to …

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that phenotypically
resemble conventional secondary lymphoid organs and are commonly found at sites of …

High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function
of the immune system, by providing communication between the body and lymph nodes …

Purpose: A precise understanding of the mechanisms by which human immune cell subsets
affect tumor biology will be critical for successful treatment of cancer using …

Targeting inhibitory immune checkpoint molecules has dramatically changed treatment
paradigms in medical oncology. Understanding the best strategies to unleash a pre-existing …

The prevalence of thyroid carcinoma is increasing and represents the most common
endocrine malignancy, with papillary thyroid carcinoma (PTC) being the most frequent …