Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

LCC Lee, KKW Lo - Small Methods, 2024 - Wiley Online Library
Despite the advent of various medical interventions for cancer treatment, the disease
continues to pose a formidable global health challenge, necessitating the development of …

Iridium (III)-Based Infrared Two-Photon Photosensitizers: Systematic Regulation of Their Photodynamic Therapy Efficacy

XL Li, LZ Zeng, R Yang, XD Bi, Y Zhang… - Inorganic …, 2023 - ACS Publications
Cyclometalated iridium (III) complexes are of significant importance in the field of antitumor
photodynamic therapy (PDT), whether they exist as single molecules or are incorporated …

Potent BODIPY-based photosensitisers for selective mitochondrial dysfunction and effective photodynamic therapy

ERH Walter, PKK Leung, LCC Lee, KKW Lo… - Journal of Materials …, 2024 - pubs.rsc.org
The development of new and improved mitochondria-targeting photosensitisers (PSs) for
photodynamic therapy (PDT) remains highly desirable, due to the critical role the …

New cyclometalated iridium (III) complexes bearing substituted 2-(1H-benzimidazol-2-yl) quinoline: synthesis, characterization, electrochemical and anticancer studies

C Sahin, D Mutlu, A Erdem, R Kilincarslan, S Arslan - Bioorganic Chemistry, 2024 - Elsevier
New iridium (III) compounds (C 1–C 3) bearing 2-(1H-benzimidazol-2-yl) quinoline ligands
with different side groups (benzyl, 2, 3, 4, 5, 6-pentamethylbenzyl and 2, 3, 4, 5, 6 …

Exploiting the Potential of Iridium(III) bis-Nitrone Complexes as Phosphorogenic Bifunctional Reagents for Phototheranostics

ECL Mak, Z Chen, LCC Lee, PKK Leung… - Journal of the …, 2024 - ACS Publications
Cross-linking strategies have found wide applications in chemical biology, enabling the
labeling of biomolecules and monitoring of protein–protein interactions. Nitrone exhibits …

Recent Advances in Organometallic NIR Iridium (III) Complexes for Detection and Therapy

S Jing, X Wu, D Niu, J Wang, CH Leung, W Wang - Molecules, 2024 - mdpi.com
Iridium (III) complexes are emerging as a promising tool in the area of detection and therapy
due to their prominent photophysical properties, including higher photostability, tunable …

Organometallic d6, d8 and d10 metal complexes for biosensing and imaging, cancer therapy and theranosis

YY Lam, NS Lee, SF Lee, CYS Chung - Journal of Organometallic …, 2024 - Elsevier
Organometallic d 6, d 8 and d 10 metal complexes are known for their interesting
photophysical and photochemical properties. This allows many of them to develop into …