[PDF][PDF] Transport of complex and active fluids in porous media
Complex and active fluids find broad applications in flows through porous materials.
Nontrivial rheology can couple to porous microstructure leading to surprising flow patterns …
Nontrivial rheology can couple to porous microstructure leading to surprising flow patterns …
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route
B Rama, AJ Ribeiro - Expert Opinion on Drug Delivery, 2023 - Taylor & Francis
Introduction Subcutaneous physiology is distinct from other parenteral routes that benefit the
administration of prolonged-release formulations. A prolonged-release effect is particularly …
administration of prolonged-release formulations. A prolonged-release effect is particularly …
Modeling large-volume subcutaneous injection of monoclonal antibodies with anisotropic porohyperelastic models and data-driven tissue layer geometries
Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has become one of
the fastest-growing fields in the pharmaceutical industry. The transport and mechanical …
the fastest-growing fields in the pharmaceutical industry. The transport and mechanical …
Computational modeling of the effect of skin pinch and stretch on subcutaneous injection of monoclonal antibodies using autoinjector devices
Subcutaneous injection of monoclonal antibodies (mAbs) has experienced unprecedented
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
growth in the pharmaceutical industry due to its benefits in patient compliance and cost …
Hydrodynamic considerations for spring-driven autoinjector design
X Zhong, JC Veilleux, GH Shi, DS Collins… - International Journal of …, 2023 - Elsevier
In recent years, significant progress has been made in the studies of the spring-driven
autoinjector, leading to an improved understanding of this device and its interactions with …
autoinjector, leading to an improved understanding of this device and its interactions with …
Transport and distribution of biotherapeutics in different tissue layers after subcutaneous injection
The subcutaneous injection is the main route of administration for monoclonal antibodies
(mAbs) and several other biotherapeutics due to the patient comfort and cost-effectiveness …
(mAbs) and several other biotherapeutics due to the patient comfort and cost-effectiveness …
Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiology
The pharmaceutical industry has experienced a remarkable increase in the use of
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages …
Lymphatic uptake of biotherapeutics through a 3D hybrid discrete-continuum vessel network in the skin tissue
Subcutaneous administration is a common approach for the delivery of biotherapeutics,
which is achieved mainly through the absorption across lymphatic vessels. In this paper, the …
which is achieved mainly through the absorption across lymphatic vessels. In this paper, the …
Stabilized isogeometric formulation of the multi-network poroelasticity and transport model (mpet2) for subcutaneous injection of monoclonal antibodies
The MPET 2 model couples the multi-network poroelastic theory (MPET) with solute
transport equations and provides predictions of the material deformation, fluid dynamics …
transport equations and provides predictions of the material deformation, fluid dynamics …
A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans
Subcutaneous (subQ) injection is a common route for delivering biotherapeutics, wherein
pharmacokinetics is largely influenced by drug transport in a complex subQ tissue …
pharmacokinetics is largely influenced by drug transport in a complex subQ tissue …