NK Lytle, AG Barber, T Reya - Nature Reviews Cancer, 2018 - nature.com
Although we have come a long way in our understanding of the signals that drive cancer growth, and how these signals can be targeted, effective control of this disease remains a …
Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …
Several signaling pathways have been identified as important for developmental processes. One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …
The WNT signaling pathways are major regulators of organ development. Ample research over the past few decades revealed that these pathways are critically involved in adult tissue …
S Söderholm, C Cantù - WIREs Mechanisms of Disease, 2021 - Wiley Online Library
Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in which β‐catenin drives the expression of certain genes as a consequence of the trigger …
S Ganesh, X Shui, KP Craig, J Park, W Wang… - Molecular Therapy, 2018 - cell.com
Wnt/β-catenin signaling mediates cancer immune evasion and resistance to immune checkpoint therapy, in part by blocking cytokines which trigger immune cell recruitment …
H Wang, G Deng, M Ai, Z Xu, T Mou, J Yu, H Liu… - Oncogene, 2019 - nature.com
Hsp90ab1 is upregulated in numerous solid tumors, which is thought to induce the angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) …
JA Schneider, TW Craven, AC Kasper, C Yun… - Nature …, 2018 - nature.com
New chemical inhibitors of protein–protein interactions are needed to propel advances in molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to …
PS Aghbash, N Hemmat, B Baradaran… - Oncology …, 2023 - pmc.ncbi.nlm.nih.gov
Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV …