Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

YS Jung, JI Park - Experimental & Molecular Medicine, 2020 - nature.com
Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Stem cell fate in cancer growth, progression and therapy resistance

NK Lytle, AG Barber, T Reya - Nature Reviews Cancer, 2018 - nature.com
Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Wnt signaling and its significance within the tumor microenvironment: novel therapeutic insights

S Patel, A Alam, R Pant, S Chattopadhyay - Frontiers in immunology, 2019 - frontiersin.org
Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

The multidimensional role of the Wnt/β‐catenin signaling pathway in human malignancies

IS Hiremath, A Goel, S Warrier… - Journal of Cellular …, 2022 - Wiley Online Library
Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

The WNT signaling pathways in wound healing and fibrosis

O Burgy, M Königshoff - Matrix Biology, 2018 - Elsevier
The WNT signaling pathways are major regulators of organ development. Ample research
over the past few decades revealed that these pathways are critically involved in adult tissue …

The WNT/β‐catenin dependent transcription: A tissue‐specific business

S Söderholm, C Cantù - WIREs Mechanisms of Disease, 2021 - Wiley Online Library
Abstract β‐catenin‐mediated Wnt signaling is an ancient cell‐communication pathway in
which β‐catenin drives the expression of certain genes as a consequence of the trigger …

RNAi-mediated β-catenin inhibition promotes T cell infiltration and antitumor activity in combination with immune checkpoint blockade

S Ganesh, X Shui, KP Craig, J Park, W Wang… - Molecular Therapy, 2018 - cell.com
Wnt/β-catenin signaling mediates cancer immune evasion and resistance to immune
checkpoint therapy, in part by blocking cytokines which trigger immune cell recruitment …

Hsp90ab1 stabilizes LRP5 to promote epithelial–mesenchymal transition via activating of AKT and Wnt/β-catenin signaling pathways in gastric cancer progression

H Wang, G Deng, M Ai, Z Xu, T Mou, J Yu, H Liu… - Oncogene, 2019 - nature.com
Hsp90ab1 is upregulated in numerous solid tumors, which is thought to induce the
angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) …

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

JA Schneider, TW Craven, AC Kasper, C Yun… - Nature …, 2018 - nature.com
New chemical inhibitors of protein–protein interactions are needed to propel advances in
molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to …

The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer

PS Aghbash, N Hemmat, B Baradaran… - Oncology …, 2023 - pmc.ncbi.nlm.nih.gov
Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the
main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV …