Epigenetic mechanisms in drug relapse
A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …
Signals from the fourth dimension regulate drug relapse
Despite the enormous societal burden of alcohol and drug addiction and abundant research
describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for …
describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for …
Molecular, circuit, and stress response characterization of ventral pallidum Npas1-neurons
G Morais-Silva, RR Campbell, H Nam… - Journal of …, 2023 - Soc Neuroscience
Altered activity of the ventral pallidum (VP) underlies disrupted motivation in stress and drug
exposure. The VP is a very heterogeneous structure composed of many neuron types with …
exposure. The VP is a very heterogeneous structure composed of many neuron types with …
Drp1 mitochondrial fission in D1 neurons mediates behavioral and cellular plasticity during early cocaine abstinence
Altered brain energy homeostasis is a key adaptation occurring in the cocaine-addicted
brain, but the effect of cocaine on the fundamental source of energy, mitochondria, is …
brain, but the effect of cocaine on the fundamental source of energy, mitochondria, is …
A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons
S Espeso-Gil, T Halene, J Bendl, B Kassim… - Genome medicine, 2020 - Springer
Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain's
neuronal population and mediate cognition, food intake, and metabolism. MDN are also …
neuronal population and mediate cognition, food intake, and metabolism. MDN are also …
Bidirectional synaptic structural plasticity after chronic cocaine administration occurs through Rap1 small GTPase signaling
Dendritic spines are the sites of most excitatory synapses in the CNS, and opposing
alterations in the synaptic structure of medium spiny neurons (MSNs) of the nucleus …
alterations in the synaptic structure of medium spiny neurons (MSNs) of the nucleus …
Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence
Relapse vulnerability in substance use disorder is attributed to persistent cue-induced drug
seeking that intensifies (or “incubates”) during drug abstinence. Incubated cocaine seeking …
seeking that intensifies (or “incubates”) during drug abstinence. Incubated cocaine seeking …
Transcriptional mechanisms of drug addiction
P Bali, PJ Kenny - Dialogues in Clinical Neuroscience, 2019 - Taylor & Francis
Drugs of abuse can modify gene expression in brain reward and motivation centers, which
contribute to the structural and functional remodeling of these circuits that impacts the …
contribute to the structural and functional remodeling of these circuits that impacts the …
Role of long noncoding RNA Gas5 in cocaine action
Abstract Background Long noncoding RNAs (lncRNAs) are a class of transcribed RNA
molecules greater than 200 nucleotides in length. Although lncRNAs do not encode …
molecules greater than 200 nucleotides in length. Although lncRNAs do not encode …
Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward
Psychostimulant exposure alters the activity of ventral pallidum (VP) projection neurons.
However, the molecular underpinnings of these circuit dysfunctions are unclear. We used …
However, the molecular underpinnings of these circuit dysfunctions are unclear. We used …