Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Neural stem/precursor cells in the adult brain reside in the subventricular zone (SVZ) of the
lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus …

Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …

Eph tyrosine kinase receptors and their ephrin ligands are expressed in most adult stem cell
niches and in many types of tumors. They maintain tissue homeostasis by controlling the …

Traumatic brain injury (TBI) is common in both civilian and military life, placing a large
burden on survivors and society. However, with the recognition of neural stem cells in adult …

In adult mammals, under physiological conditions, neurogenesis, the process of generating
new functional neurons from precursor cells, occurs mainly in two brain areas: the …

Traumatic and nontraumatic brain injury results from severe disruptions in the cellular
microenvironment leading to massive loss of neuronal populations and increased …

The use of mouse models in traumatic brain injury (TBI) has several advantages compared
to other animal models including low cost of breeding, easy maintenance, and innovative …

Insulin-like growth factor 1 (IGF1) has potent trophic effects on normal or injured intestinal
epithelium, but specific effects on intestinal stem cells (ISCs) are undefined. We used Sox9 …

Traumatic brain injury (TBI) elicits the immediate production of proinflammatory cytokines
which participate in regulating the immune response. While the mechanisms of adaptive …