Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

Myocardial injury after noncardiac surgery is defined by elevated postoperative cardiac
troponin concentrations that exceed the 99th percentile of the upper reference limit of the …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns
remain about the potential adverse effects, particularly vascular occlusive events, that may …

Background: Among patients having noncardiac surgery, perioperative hemodynamic
abnormalities are associated with vascular complications. Uncertainty remains about what …

Intraoperative hypotension is common during noncardiac surgery and associated with
myocardial injury, acute kidney injury, and death. Postoperative hypotension is also …

Perioperative stroke is a potentially devastating complication in patients undergoing
noncardiac, nonneurological surgery. This scientific statement summarizes established risk …

Background: Preliminary data suggest that preoperative N-terminal pro–B-type natriuretic
peptide (NT-proBNP) may improve risk prediction in patients undergoing noncardiac …

Importance The time interval between COVID-19 infection and surgery is a potentially
modifiable but understudied risk factor for postoperative complications. Objective To …

Background Timely identification of patients at a high risk of clinical deterioration is key to
prioritizing care, allocating resources effectively, and preventing adverse outcomes. Vital …