Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic
or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; …

Oxidative stress plays an important role in the pathogenesis of various chronic liver diseases
(CLD) and increasing evidence have confirmed the contributory role of oxidative stress in …

The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory
and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins …

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

This review addresses recent advances in specific mechanisms of hepatotoxicity. Because
of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …

Mammalian cytochromes P450 (P450) are a family of heme-thiolate enzymes involved in the
oxidative metabolism of a variety of endogenous and exogenous lipophilic compounds …

Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine. We investigated the role of
NADPH oxidase in Ang II–induced effects in hepatic stellate cells (HSCs), a fibrogenic cell …