Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-
CMs) is essential for their effective application in models of cardiac toxicity and disease …

Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent
endocytosis (CDE) for the control of cellular processes during development and in tissue …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

The Myc oncoprotein family comprises transcription factors that control multiple cellular
functions and are widely involved in oncogenesis. Here we report the identification of Myc …

Mechanotransduction refers to the conversion of mechanical forces into biochemical or
electrical signals that initiate structural and functional remodeling in cells and tissues. The …

Congenital heart diseases are some of the most common human birth defects. Though some
congenital heart defects can be surgically corrected, treatment options for other congenital …

Physical loading is a potent stimulus required to maintain bone homeostasis, partly through
the renewal and osteogenic differentiation of mesenchymal stem cells (MSCs). However, the …

Primary cilia are immotile appendages that have evolved to receive and interpret a variety of
different extracellular cues. Cilia play crucial roles in intercellular communication during …