[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …
types with specific spatial distribution patterns and structural and functional properties …
From progenitors to progeny: shaping striatal circuit development and function
R Knowles, N Dehorter, T Ellender - Journal of Neuroscience, 2021 - Soc Neuroscience
Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …
circuits is essential to provide insight into striatal function in health and disease. In this …
Cellular taxonomy of the mouse striatum as revealed by single-cell RNA-seq
The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …
Striatal circuit development and its alterations in Huntington's disease
M Lebouc, Q Richard, M Garret, J Baufreton - Neurobiology of Disease, 2020 - Elsevier
Huntington's disease (HD) is an inherited neurodegenerative disorder that usually starts
during midlife with progressive alterations of motor and cognitive functions. The disease is …
during midlife with progressive alterations of motor and cognitive functions. The disease is …
[HTML][HTML] Continuous and discrete neuron types of the adult murine striatum
The mammalian striatum is involved in many complex behaviors and yet is composed
largely of a single neuron class: the spiny projection neuron (SPN). It is unclear to what …
largely of a single neuron class: the spiny projection neuron (SPN). It is unclear to what …
Neuronal cell types, projections, and spatial organization of the central amygdala
The central amygdala (CEA) has been richly studied for interpreting function and behavior
according to specific cell types and circuits. Such work has typically defined molecular cell …
according to specific cell types and circuits. Such work has typically defined molecular cell …
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum
Z Su, Z Wang, S Lindtner, L Yang, Z Shang… - …, 2022 - journals.biologists.com
The striatum is a central regulator of behavior and motor function through the actions of D1
and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic …
and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic …
Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems
Genomic enhancer elements regulate gene expression programs important for neuronal fate
and function and are implicated in brain disease states. Enhancers undergo bidirectional …
and function and are implicated in brain disease states. Enhancers undergo bidirectional …
SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
Z Xu, Q Liang, X Song, Z Zhang, S Lindtner… - …, 2018 - journals.biologists.com
Dopamine receptor DRD1-expressing medium spiny neurons (D1 MSNs) and dopamine
receptor DRD2-expressing medium spiny neurons (D2 MSNs) are the principal projection …
receptor DRD2-expressing medium spiny neurons (D2 MSNs) are the principal projection …
The zinc finger transcription factor Sp9 is required for the development of striatopallidal projection neurons
Striatal medium-sized spiny neurons (MSNs), composed of striatonigral and striatopallidal
neurons, are derived from the lateral ganglionic eminence (LGE). We find that the …
neurons, are derived from the lateral ganglionic eminence (LGE). We find that the …