Toward targeting inflammasomes: insights into their regulation and activation

S Christgen, DE Place, TD Kanneganti - Cell research, 2020 - nature.com
Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

Renal plasticity revealed through reversal of polycystic kidney disease in mice

K Dong, C Zhang, X Tian, D Coman, F Hyder, M Ma… - Nature …, 2021 - nature.com
Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs
when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second …

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

F Yao, Z Jin, Z Zheng, X Lv, L Ren, J Yang… - Cell Death …, 2022 - nature.com
Abstract Histone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily,
participates in various cardiovascular diseases. Recent evidence showed that pyroptosis …

Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways

IE Krabbendam, B Honrath, C Culmsee, AM Dolga - Cell Calcium, 2018 - Elsevier
Abstract Ca 2+-activated K+ channels (K Ca) are expressed at the plasma membrane and in
cellular organelles. Expression of all K Ca channel subtypes (BK, IK and SK) has been …

[HTML][HTML] Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina

X Yang, C Luo, J Cai, DW Powell, D Yu… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: This study aimed to determine retinal proteomic alterations in human glaucoma,
with particular focus on links to TNF-α/TNFR1 signaling. Methods.: Human retinal protein …

Targeted-lung delivery of dexamethasone using gated mesoporous silica nanoparticles. A new therapeutic approach for acute lung injury treatment

A García-Fernández, M Sancho, V Bisbal… - Journal of Controlled …, 2021 - Elsevier
Acute lung injury (ALI) is a critical inflammatory syndrome, characterized by increased
diffuse inflammation and severe lung damage, which represents a clinical concern due to …

Isoliquiritigenin from licorice flavonoids attenuates NLRP3-mediated pyroptosis by SIRT6 in vascular endothelial cells

J He, Y Deng, L Ren, Z Jin, J Yang, F Yao, Y Liu… - Journal of …, 2023 - Elsevier
Ethnopharmacologic relevance Licorice is a traditional Chinese medicine that has been
used for cardiovascular diseases. Recent studies found that supplementation with licorice …

NF-κB mediates tumor necrosis factor α-induced expression of optineurin, a negative regulator of NF-κB

C Sudhakar, A Nagabhushana, N Jain, G Swarup - PloS one, 2009 - journals.plos.org
Optineurin is a ubiquitously expressed multifunctional cytoplasmic protein encoded by
OPTN gene. The expression of optineurin is induced by various cytokines. Here we have …

Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

A Nagabhushana, M Bansal, G Swarup - PloS one, 2011 - journals.plos.org
The nuclear factor kappa B (NF-κB) regulates genes that function in diverse cellular
processes like inflammation, immunity and cell survival. The activation of NF-κB is tightly …

Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death

A Gomez, A Serrano, E Salero, A Tovar… - Experimental eye …, 2021 - Elsevier
Purpose Chronic corneal endothelial cell (CEC) loss results in corneal edema and vision
loss in conditions such as pseudophakic bullous keratopathy (PBK), Fuchs' dystrophy, and …