Trajectory modelling techniques have been developed to determine subgroups within a
given population and are increasingly used to better understand intra-and inter-individual …

Male antisocial behaviour is concentrated in the adolescent period of the life course, as
documented by the curve of crime over age. This article reviews recent evidence regarding …

Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration
prior to old age is associated with dementia incidence. Using data from 7959 participants of …

Abstract The use of Linear Mixed-effects Models (LMMs) is set to dominate statistical
analyses in psychological science and may become the default approach to analyzing …

Background Identifying modifiable risk factors is essential to reduce the prevalence
adolescent depression. Self-report data suggest that physical activity and sedentary …

Background Lifetime lung function is related to quality of life and longevity. Over the lifespan,
individuals follow different lung function trajectories. Identification of these trajectories, their …

Background Interest in lifetime lung function trajectories has increased in the context of
emerging evidence that chronic obstructive pulmonary disease (COPD) can arise from …

Background Sleep duration has been shown to be associated with individual chronic
diseases but its association with multimorbidity, common in older adults, remains poorly …

Objective To examine the association between alcohol consumption and risk of dementia.
Design Prospective cohort study. Setting Civil service departments in London (Whitehall II …

Purpose Sepsis is a heterogeneous syndrome and identification of sub-phenotypes is
essential. This study used trajectories of vital signs to develop and validate sub-phenotypes …