The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Primary aldosteronism is a common cause of secondary hypertension associated with
excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it …

Primary aldosteronism is a common cause of hypertension and is a risk factor for
cardiovascular and renal morbidity and mortality, via mechanisms mediated by both …

Primary aldosteronism (PA), the most common form of secondary hypertension, can be
either surgically cured or treated with targeted pharmacotherapy. PA is frequently …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Primary aldosteronism (PA) is the most common form of secondary hypertension. In many
cases, somatic mutations in ion channels and pumps within adrenal cells initiate the …

Context Somatic mutations have been identified in more than half of aldosterone-producing
adenomas (APAs) through mutation hotspot sequencing. The underlying pathogenesis of …

Driver somatic mutations for aldosterone excess have been found in≈ 90% of aldosterone-
producing adenomas (APAs) using an aldosterone synthase (CYP11B2)-guided …

Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …

Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …