Decoding thrombosis through code: a review of computational models

NG Gutiérrez, D Mukherjee, D Bark Jr - Journal of Thrombosis and …, 2024 - Elsevier
From the molecular level up to a blood vessel, thrombosis and hemostasis involves many
interconnected biochemical and biophysical processes over a wide range of length and time …

Delivery of nitric oxide in the cardiovascular system: implications for clinical diagnosis and therapy

T Ma, Z Zhang, Y Chen, H Su, X Deng, X Liu… - International Journal of …, 2021 - mdpi.com
Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery
is highly associated with the occurrence and development of cardiovascular disease (CVD) …

Blood viscosity in subjects with type 2 diabetes mellitus: roles of hyperglycemia and elevated plasma fibrinogen

J Sun, K Han, M Xu, L Li, J Qian, L Li, X Li - Frontiers in Physiology, 2022 - frontiersin.org
The viscosity of blood is an indicator in the understanding and treatment of disease. An
elevated blood viscosity has been demonstrated in patients with Type 2 Diabetes Mellitus …

Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen

H Li, Y Qiang, X Li, C Brugnara, PA Buffet… - Proceedings of the …, 2024 - pnas.org
The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human
spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior …

Multiphysics and multiscale modeling of microthrombosis in COVID-19

H Li, Y Deng, Z Li, A Dorken Gallastegi… - PLOS Computational …, 2022 - journals.plos.org
Emerging clinical evidence suggests that thrombosis in the microvasculature of patients with
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …

In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease

G Li, Y Qiang, H Li, X Li, M Dao, GE Karniadakis - Biophysical Journal, 2023 - cell.com
Erythrophagocytosis occurring in the spleen is a critical process for removing senescent and
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …

Cell-scale hemolysis evaluation of intervenient ventricular assist device based on dissipative particle dynamics

Z Xu, C Chen, P Hao, F He, X Zhang - Frontiers in Physiology, 2023 - frontiersin.org
Most of the existing hemolysis mechanism studies are carried out on the macro flow scale.
They assume that the erythrocyte membranes with different loads will suffer the same …

[PDF][PDF] 耗散粒子动力学方法在生物学领域的应用与研究进展: 从蛋白质结构到细胞力学

唐梓涵, 李学进, 李德昌 - 科学通报, 2023 - researchgate.net
摘要耗散粒子动力学(dissipative particle dynamics, DPD) 是近年发展起来的一种介观尺度的
数值模拟方法, 是研究软物质和复杂流体动力学行为的一种重要手段. 这种新型介观模拟方法 …

Quantifying shear-induced margination and adhesion of platelets in microvascular blood flow

L Li, S Wang, K Han, X Qi, S Ma, L Li, J Yin, D Li… - Journal of Molecular …, 2023 - Elsevier
Platelet margination and adhesion are two critical and closely related steps in thrombus
formation. Using dissipative particle dynamics (DPD) method that seamlessly models blood …

Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics

G Li, H Li, PA Ndou, M Franco, X Li, I MacDonald… - Computers in Biology …, 2024 - Elsevier
The spleen constantly clears altered red blood cells (RBCs) from the circulation, tuning the
balance between RBC formation (erythropoiesis) and removal. The retention and …