The 2022 WHO classification reflects increases in the knowledge of the underlying
pathogenesis of parathyroid disease. In addition to the classic characteristic features of …

Recent data suggest an increase in the overall incidence of parathyroid disorders, with
primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is …

Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel
immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable …

The majority of parathyroid disease encountered in routine practice is due to single
parathyroid adenoma, of which the majority arise as sporadic tumors. This is usually a …

Parathyroid tumors are rare endocrine neoplasms affecting 0.1–0.3% of the general
population, including benign parathyroid adenomas (PAs; about 98% of cases) …

Immunohistochemistry remains an indispensable tool in diagnostic surgical pathology. In
parathyroid tumours, it has four main applications: to detect (1) loss of parafibromin;(2) other …

Parathyroid carcinoma (PC) is one of the rarest and aggressive malignancies of the
endocrine system. In some instances the histological diagnosis remains uncertain unless …

Cancer is responsible for more than 10 million deaths every year. Metastasis and drug
resistance lead to a poor survival rate and are a major therapeutic challenge. Substantial …

Introduction Parathyroid cancers are rare and difficult to distinguish from benign parathyroid
tumours. Prediction of malignancy often relies on intraoperative assessment of invasion …

Long non-coding RNAs (lncRNAs) are an important class of epigenetic regulators involved
in both physiological processes and cancer development. Preliminary evidence suggested …