Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Benzimidazole, the benzo derivative of imidazole, is a class of bicyclic aromatic organic
compound consisting of six‐membered benzene ring fused to five‐membered imidazole at 4 …

Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …

Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

To promote the development of novel agricultural succinate dehydrogenase inhibitor (SDHI)
fungicides, we introduced cinnamamide and nicotinamide structural fragments into the …

Cancer is associated with uncontrolled cell proliferation invading adjoining tissues and
organs. Despite the availability of several chemotherapeutic agents, the constant search for …

In this work, we utilized the N-benzylaryl derivative 9 as a lead compound and employed the
molecular hybridization strategy by introducing cinnamoyl fragments to successfully design …

Aim: A fragment-based design and synthesis of three novel series of aminopyridone-linked
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …