Bile acids, the water-soluble, amphipathic end products of cholesterol metabolism, are
involved in liver, biliary, and intestinal disease. Formed in the liver, bile acids are absorbed …

Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

The progressive familial intrahepatic cholestases (PFIC) are a group of inherited disorders
with severe cholestatic liver disease from early infancy. A subgroup characterized by normal …

The principles of inter‐species dose extrapolation are poorly understood and applied. We
provide an overview of the principles underlying dose scaling for size and dose adjustment …

Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular
identity of the involved ATP-dependent carrier protein has not been elucidated. We cloned …

The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of
several conjugated compounds across the apical membrane of the hepatocyte into the bile …

Cholestasis, or impaired bile flow, is an important but poorly understood manifestation of
liver disease. Two clinically distinct forms of inherited cholestasis, benign recurrent …

Bile acids, amphipathic end products of cholesterol metabolism, are “good” in the infant
because they enhance lipid absorption and thereby promote growth. Bile acids also induce …

We identified three novel transporters structurally belonging to the organic anion
transporting polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do …