Abstract Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), a component of
Gram-negative bacteria to induce production of pro-inflammatory mediators aiming at …

Mast-cell activation mediated by the high-affinity receptor for IgE (FcεRI) is considered to be
a key event in the allergic inflammatory response. However, in a physiological setting, other …

The impact of covalent binding on PROTAC-mediated degradation of BTK was investigated
through the preparation of both covalent binding and reversible binding PROTACs derived …

The high-affinity Fc receptor for IgE (FcεRI), a multimeric immune receptor, is a crucial
structure for IgE-mediated allergic reactions. In recent years, advances have been made in …

This review summarizes recent developments in our understanding of the molecular basis of
platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and …

Natural killer (NK) cell immune responses are regulated by a balance of activating and
inhibitory signals transmitted by cell surface receptors. Immunoreceptor tyrosine-based …

The mast cell is a central player in allergy and asthma. Activation of these cells induces the
release of preformed inflammatory mediators localized in specialized granules and the de …

Review of the intracellular pathway of TREM-1 signaling, its interactions with PRR pathways,
focusing on TLRs and NLRs. TREM-1 is an important signaling receptor expressed on …

The transcription factor Pax5 represses lineage-inappropriate genes and activates B cell-
specific genes in B lymphocytes. By identifying 110 Pax5-repressed genes, we now …

Palmitate, a 16-carbon saturated fatty acid, is attached to more than 100 proteins.
Modification of proteins by palmitate has pleiotropic effects on protein function …