The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Increased sympathetic activity is a well-known pathophysiological mechanism in insulin
resistance (IR) and hypertension (HT). The carotid bodies (CB) are peripheral …

The rat retrotrapezoid nucleus (RTN) contains pH‐sensitive neurons that are putative central
chemoreceptors. Here, we examined whether these neurons respond to peripheral …

A workshop was held at the National Institute for Diabetes and Digestive and Kidney
Diseases with a focus on the impact of sleep and circadian disruption on energy balance …

Obstructive sleep apnea (OSA) is a common sleep disorder, effecting 17% of the total
population and 40–70% of the obese population (,). Multiple studies have identified OSA as …

The mammalian carotid body is a small chemosensory organ that helps maintain the
chemical composition of arterial blood via reflex control of ventilation. Thus, in response to …

The control of breathing depends critically on sensory inputs to the central pattern generator
of the brainstem, arising from peripheral arterial chemoreceptors located principally in the …

Arterial chemoreceptors play a vital role in cardiorespiratory control by providing the brain
with information regarding blood oxygen, carbon dioxide, and pH. The main chemoreceptor …

Hypoglycemia poses a serious threat to the integrity of the brain, owing to its reliance on
blood glucose as a fuel. Protecting against hypoglycemia is an extended network of glucose …