Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small
GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous …

Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is
associated with cardiomyocyte death and development of fibrosis. The fibrotic process is …

Cells respond to environmental cues by mobilizing signal transduction cascades that
engage protein kinases and phosphoprotein phosphatases. Correct organization of these …

In mammals, conservation of body water is critical for survival and is dependent on the
kidneys' ability to minimize water loss in the urine during periods of water deprivation. The …

Renal collecting duct principal cells play a key role in controlling body water balance.
Principal cells express the water channels AQP2, AQP3, and AQP4 that mediate renal water …

The alteration of water balance and related disorders has emerged as being strictly linked to
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …

A-kinase anchoring proteins (AKAPs) and cyclic nucleotide phosphodiesterases (PDEs) are
essential enzymes in the cyclic adenosine 3′-5′ monophosphate (cAMP) signaling …

Heart failure is a complex clinical syndrome, represented as an impairment in ventricular
filling and myocardial blood ejection. As such, heart failure is one of the leading causes of …

The molecular mechanisms underlying chronic kidney disease (CKD) are poorly understood
and treatment options are limited, a situation underpinning the need for elucidating the …