Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the
engagement of RCD pathways does not inevitably result in cell death. Instead, RCD …

The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell
differentiation in the host immune response; however, the uncontrollable stimulation of NF …

Cell migration occurs in confined microenvironments, which plays a vital role in the process
of tumor metastasis. However, it is challenging to study their behaviors in vivo. Here we …

Metastatic cancer cells can develop anoikis resistance in the absence of substrate
attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria …

Cell death is a necessary event in life and is crucial for the regulation of organismal
development, homeostasis, aging and pathological conditions. There are different modes of …

Mechanical features of cancer cells emerge as a distinct trait during development and
progression of solid tumors. Herein, we discuss recent key findings regarding the impact of …

Background Excessive extracellular matrix deposition and increased stiffness are typical
features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal …

Background Triple-negative breast cancer (TNBC) is characterized by its high metastatic
potential, which results in poor patient survival. Cancer-associated fibroblasts (CAFs) are …

Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype among breast
cancers (BCs), characterized by anoikis resistance, high invasiveness, and metastatic …