Highlights•Triazoles mimic different functional groups, resulting optimal bioisosteres for the
synthesis of new active molecules.•Triazoles present a marked stability under hydrolytic …

1, 2, 3-Triazole scaffolds are not obtained in nature, but they are still intensely investigated
by synthetic chemists in various fields due to their excellent properties and green synthetic …

Natural peptides are an important class of chemical mediators, essential for most vital
processes. What limits the potential of the use of peptides as drugs is their low bioavailability …

Motivated by evidence garnered from literature probing the use of triazoles in drug discovery
and development, we reported the utilization of bioisosteric replacement and molecular …

The design of multi‐target ligands has become an innovative approach for the identification
of effective therapeutic treatments against complex diseases, such as cancer. Recent …

This is a review of papers published in the year 2017 that focus on the synthesis, reactivity,
or properties of compounds containing a carbon-transition metal double or triple bond …

The review deals with the metal-catalyzed synthetic methods used for the construction of 5-
membered nitrogen-containing aromatic and nonaromatic heterocycles with one to three …

The ruthenium‐catalyzed azide‐alkyne cycloaddition (RuAAC) gives access to 1, 5‐
disubstitued triazoles in a single atom‐economical step and offers advantages compared to …

Epothilones are 16‐membered macrolides that act as microtubule‐targeting agents to tackle
cancer. Many synthetic analogues have been investigated for their activity, yet often based …

A systematic highlight of syntheses reported since 2006 of 1, 2, 3-triazole-fused macrocycles
possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory …