The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Mitochondrial respiratory deficiencies have been observed in numerous neurodegenerative
disorders, such as Alzheimer's and Parkinson's diseases. For decades, these reductions in …

Kynurenic acid (KynA) is tissue protective in cardiac, cerebral, renal, and retinal ischemia
models, but the mechanism is unknown. KynA can bind to multiple receptors, including the …

The maintenance of cellular function relies on the close regulation of adenosine
triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase …

In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose
metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the …

Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory
diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine …

Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical
role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic …

Aging is a major driving force underlying dementia, such as that caused by Alzheimer's
disease (AD). While the idea of targeting aging as a therapeutic strategy is not new, it …

Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …