New treatment options for critically important WHO fungal priority pathogens

L Kriegl, M Egger, J Boyer, M Hoenigl… - Clinical Microbiology and …, 2024 - Elsevier
Background Yet often overlooked in public health discourse, fungal infections pose a
crucialglobal disease burden associated with annual mortality rates approximately equal to …

Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis

E Novy, C Roger, JA Roberts, MO Cotta - Critical Care, 2023 - Springer
Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis
observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths …

Photocatalyzed Imino-Difluoromethylation of Alkenes with Bifunctional Oxime Esters

Z Chen, S Yang, L Wu, S Li, L Yang - The Journal of Organic …, 2024 - ACS Publications
Herein, we report a simple and versatile difluoromethylene-imide reaction in which a series
of olefins can undergo a difluoromethylenimine reaction under photocatalytic conditions …

Safety of rezafungin as a long-term treatment option in two patients with complicated fungal infections: two cases from Lecco Hospital (Italy)

G Ponta, V Morena, M Strano, C Molteni… - Antimicrobial Agents …, 2024 - journals.asm.org
Rezafungin is an echinocandin characterized by a long elimination half-life which allows for
weekly administration. It has been recently approved for the treatment of candidemia. Few …

The Efficacy of Hybrid Vaginal Ovules for Co-Delivery of Curcumin and Miconazole against Candida albicans

BMS Bezerra, SEDM y Araújo, JO Alves-Júnior… - Pharmaceutics, 2024 - mdpi.com
Curcumin (CUR) is a natural compound that can be combined with miconazole (MCZ) to
improve vulvovaginal candidiasis (VVC) caused by Candida albicans treatment's efficacy …

Comparative efficacy of antifungal drugs for the treatment of oral candidiasis in HIV-positive patients: A Bayesian network meta-analysis

J Lin, C Peng, W Huang - Medicina Clínica, 2024 - Elsevier
Oral candidiasis infection is particularly prevalent among individuals in HIV-positive patients.
Antifungal drugs have shown promising therapeutic effects in treating oral candidiasis in HIV …

Management of invasive candidiasis: A focus on rezafungin, ibrexafungerp, and fosmanogepix

BA August, PB Kale‐Pradhan - Pharmacotherapy: The Journal …, 2024 - Wiley Online Library
Management of invasive fungal infections is challenging with growing antifungal resistance.
Broad antifungal use has resulted in greater intrinsic and acquired resistance among …

Spectrum and management of rare Candida/yeast infections in Kuwait in the Middle East

S Ahmad, M Asadzadeh… - … Advances in Infectious …, 2024 - journals.sagepub.com
Invasive fungal infections (IFIs) are associated with high mortality rates and mostly affect
patients with compromised immunity. The incidence of IFIs is increasing worldwide with the …

Therapies in preclinical and in early clinical development for the treatment of urinary tract infections: from pathogens to therapies

V Fuochi, S Furnari, L Trovato, M Calvo… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Urinary tract infections (UTIs) are a prevalent health challenge
characterized by the invasion and multiplication of microorganisms in the urinary system …

[HTML][HTML] Ecotoxicity and Mutagenicity Assessment of Novel Antifungal Agents VT-1161 and T-2307

EGP Suarez, A Siciliano, M Spampinato, A Maione… - …, 2024 - pmc.ncbi.nlm.nih.gov
Antifungal substances are essential for managing fungal infections in humans, animals, and
plants, and their usage has significantly increased due to the global rise in fungal infections …