Although many protein variants have properties similar to their corresponding wild-type
structures, the replacement of a single amino acid often produces dramatic changes in …

A fundamental component of systems biology, proteolytic cleavage is involved in nearly all
aspects of cellular activities: from gene regulation to cell lifecycle regulation. Current …

OBJECTIVE: In recent years, several machine learning approaches have been applied to
modeling the specificity of the human immunodeficiency virus type 1 (HIV-1) protease …

The necrotrophic fungus Botrytis cinerea is reported to infect more than 220 host plants
worldwide. In phylogenetical–taxonomical terms, the pathogen is considered a complex of …

Background The human immunodeficiency virus type 1 (HIV-1) aspartic protease is an
important enzyme owing to its imperative part in viral development and a causative agent of …

Drug-resistant mutations (DRMs) in HIV-1 protease are a major challenge to antiretroviral
therapy. Protease-substrate interactions that are determined to be critical for native …

Background Predicting type-1 Human Immunodeficiency Virus (HIV-1) protease cleavage
site in protein molecules and determining its specificity is an important task which has …

Information fusion has become a powerful tool for challenging applications such as
biological prediction problems. In this paper, we apply a new information-theoretical fusion …

HIV-1 protease site helps to understand the specificity of substrates which antagonizes AIDS
by restraining the replication of HIV-1 through inhibitors. Identification of HIV-1 protease …

The substrate specificity of human immunodeficiency virus 1 (HIV-1) plays an essential role
in designing HIV-1 inhibitors for therapy purpose. Hence, to predict the existence of …