Next-generation sequencing (NGS) technologies have recently developed beyond the
research realm and started to mature into clinical applications. Here, we review the current …

The incidence of opportunistic yeast infections in humans has been increasing over recent
years. These infections are difficult to treat and diagnose, in part due to the large number …

Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA
has emerged as a promising diagnostic technology for bloodstream infections. However, a …

Objectives: Culture-based diagnostics represent the standard of care in septic patients, but
are highly insensitive and in many cases unspecific. We recently demonstrated the general …

Background There is a lack of validated tools to assess potential disease progression and
hospitalisation decisions in patients presenting to the emergency department (ED) with a …

Background This study assessed the ability of mid-regional proadrenomedullin (MR-
proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive …

The increasing incidence of bloodstream infections including sepsis is a major challenge in
intensive care units worldwide. However, current diagnostics for pathogen identification …

Next-generation sequencing (NGS) has become a widely used technology in biological
research. NGS applications for clinical pathogen detection have become vital technologies …

Here, we present a method for enrichment of double-stranded cfDNA with an average length
of∼ 40 bp from cfDNA for high-throughput DNA sequencing. This class of cfDNA is enriched …

Background Metagenomic next-generation sequencing (mNGS) has emerged as a
promising technology that enables pan-pathogen detection from any source. However …