Novel pathways of vitamin D3, lumisterol 3 (L3), and tachysterol 3 (T3) activation have been
discovered, initiated by CYP11A1 and/or CYP27A1 in the case of L3 and T3. The resulting …

Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …

The classical pathway of vitamin D activation follows the sequence D3→ 25 (OH) D3→ 1, 25
(OH) 2 D3 with the final product acting on the receptor for vitamin D (VDR). An alternative …

Melanoma represents a significant clinical problem affecting a large segment of the
population with a relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is …

New and more efficient routes of chemical synthesis of vitamin D 3 (D 3) hydroxy (OH)
metabolites, including 20S (OH) D 3, 20S, 23S (OH) 2 D 3 and 20S, 25 (OH) 2 D 3, that are …

Abstract 20 S-hydroxyvitamin D3 [20 S (OH) D3] is anti-inflammatory and not hypercalcemic,
suggesting its potential as a lead compound. In this study, side chain modified 20 S (OH) D3 …

Vitamin D plays a crucial role in regulation of the immune response. However, treatment of
autoimmune diseases with 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] doses sufficient to be …

Abstract 1α, 20 S-Dihydroxyvitamin D3 [1, 20 S (OH) 2D3], a natural and bioactive vitamin
D3 metabolite, was chemically synthesized for the first time. X-ray crystallography analysis of …

The vitamin D3 metabolite, 20 S, 23 S-dihydroxyvitamin D3, was chemically synthesized for
the first time and identified to be the same as the enzymatically produced metabolite. The …

Phytochemical investigation on the fruiting bodies of the medicinal fungus Ganoderma
lingzhi led to the isolation of a new norsteroid, namely ganonorsterone A (1), together with …