Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Metastasis, the spread of cancer from a primary site to distant organs, is an important
challenge in oncology. This Review explores the complexities of immune escape …

High-grade serous ovarian cancers have low survival rates because of their late
presentation with extensive peritoneal metastases and frequent chemoresistance, and …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …

Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …

The interferons (IFNs) are a primary defense against pathogens because of the strong
antiviral activities they induce. IFNs can be classified into three groups: type I, type II and …

Although Zika virus (ZIKV) can be transmitted sexually and cause congenital birth defects,
immune control mechanisms in the female reproductive tract (FRT) are not well …

Type I and type III interferons (IFNs) are major components in activating the innate immune
response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and …

Teleost type I interferons (IFNs) are categorized into group I and II subgroups that bind to
distinct receptors to activate antiviral responses. However, the interaction between ifn …