Intracellular Ca2 is the central regulator of cardiac contrac-tility. Moreover, it is becoming
increasingly apparent that alterations in myocyte Ca2 regulation may be critically important …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The roles of the sarcoplasmic reticulum (SR) Ca (2+)‐ATPase and Na (+)‐Ca2+ exchange in
Ca2+ removal from cytosol were compared in isolated rabbit and rat ventricular myocytes …

The release of sarcoplasmic reticulum (SR) Ca in cardiac muscle during excitation-
contraction coupling is known to be graded by the amount of activating Ca outside the SR …

The compound fura-2 (Grynkiewicz et al., J. Biol. Chem. 260, 3440–3450, 1985) is generally
known as an indicator dye for measuring the concentration of free calcium ([Ca2+]) inside …

Enhanced cardiac diastolic Ca leak from the sarcoplasmic reticulum (SR) ryanodine
receptor may reduce SR Ca content and contribute to arrhythmogenesis. We tested whether …

The control of intracellular calcium is central to regulation of contractile force in cardiac
muscle. This review illustrates how analysis of the control of calcium requires an integrated …

Increases in heart rate are accompanied by acceleration of relaxation. This effect is apparent
at the single myocyte level and depends on sarcoplasmic reticulum (SR) Ca transport and …

Although each of the fundamental processes involved in excitation-contraction coupling in
mammalian heart has been identified, many quantitative details remain unclear. The initial …