Brain injury following transient or permanent focal cerebral ischaemia (stroke) develops from
a complex series of pathophysiological events that evolve in time and space. In this article …

1. Stroke is the neurological evidence of a critical reduction of cerebral blood flow in a
circumscribed part of the brain, resulting from the sudden or gradually progressing …

Ischaemic stroke is a leading cause of death and long-lasting disability. Several
neuroprotective drugs have been developed that have the potential to limit ischaemic brain …

NEUROPROTECTION MAY BE DEFINED AS the “pre-vention or amelioration of neuronal
damage evidenced by abnormalities in cerebral metabolism, histopathology or neurologic …

In vivo two-photon microscopy was used to image in real time dendrites and their spines in a
mouse photothrombotic stroke model that reduced somatosensory cortex blood flow in …

Inflammation and oxidative stress are involved in brain damage following stroke, and
tryptophan oxidation along the kynurenine pathway contributes to the modulation of …

Background Stroke is a leading cause of long-term disability. All neuroprotectants targeting
excitotoxicity have failed to become stroke medications. In order to explore and identify new …

A body of evidence suggests that the mechanisms of excitotoxic neuronal damage evoked
by excessive or prolonged activation of the excitatory amino acid receptors may be involved …

The high energy requirements compared to the low energy reserves render the brain
particularly vulnerable to hypoxic conditions. To protect the brain against hypoxia, powerful …

Brain injury after focal cerebral ischemia, the most common cause of stroke, develops from a
series of pathological processes, including excitotoxicity, inflammation, and apoptosis. While …