Extensive work has characterized endoplasmic reticulum (ER) and mitochondrial stress
responses. In contrast, very little has been published about stress responses in lysosomes; …

Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-
lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal …

Purpose Photoreceptor degeneration occurs in various retinal diseases including age-
related macular degeneration (AMD), Retinitis pigmentosa (RP), and diabetic retinopathy …

Diabetic retinopathy (DR) is a devastating disease leading to blindness among majority of
working adults around the globe. Nonetheless, an effective treatment or cure for the disease …

Due to increased drug and radiation tolerance, there is an urgent need to develop novel
anticancer agents. In our previous study, we performed a series of structural modifications of …

Multiciliated cells (MCCs) are extremely highly differentiated, presenting> 100 cilia and
basal bodies. Therefore, MCC fate is thought to be terminal and irreversible. We analyzed …

Amyloid-β peptide (Aβ) accumulation in the brain is a hallmark of Alzheimer's Disease. An
important mechanism of Aβ clearance in the brain is uptake and degradation by microglia …

Aim and background A growing body of evidence supports the impact of intermittent fasting
(IF) on longevity and healthy aging via the modulation of autophagy genes. The activation of …

Background Sepsis is a systemic inflammatory disease caused by multiple pathogens, with
the most commonly affected organ being the lung. 3-Hydroxybutyrate plays a protective role …

The mechanism of myopia and the associated retinopathy remains unclear, and
dysregulated microRNAs (miRNAs) are implicated in this disease. In this research, we …