Artificial cells: past, present and future

W Jiang, Z Wu, Z Gao, M Wan, M Zhou, C Mao… - ACS nano, 2022 - ACS Publications
Artificial cells are constructed to imitate natural cells and allow researchers to explore
biological process and the origin of life. The construction methods for artificial cells, through …

Prebiotic systems chemistry: new perspectives for the origins of life

K Ruiz-Mirazo, C Briones, A de la Escosura - Chemical reviews, 2014 - ACS Publications
The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

Engineering genetic circuit interactions within and between synthetic minimal cells

KP Adamala, DA Martin-Alarcon, KR Guthrie-Honea… - Nature …, 2017 - nature.com
Genetic circuits and reaction cascades are of great importance for synthetic biology,
biochemistry and bioengineering. An open question is how to maximize the modularity of …

[HTML][HTML] Artificial cells: from basic science to applications

C Xu, S Hu, X Chen - Materials Today, 2016 - Elsevier
Artificial cells have attracted much attention as substitutes for natural cells. There are many
different forms of artificial cells with many different definitions. They can be integral biological …

Vesicle-based artificial cells as chemical microreactors with spatially segregated reaction pathways

Y Elani, RV Law, O Ces - Nature communications, 2014 - nature.com
In the discipline of bottom-up synthetic biology, vesicles define the boundaries of artificial
cells and are increasingly being used as biochemical microreactors operating in …

Biological autonomy

A Moreno, M Mossio - A philo, 2015 - Springer
If we were to point out in a few words what characterises the phenomenon of life, we would
probably mention the amazing plasticity and robustness of living systems, the innumerable …

Interfacial assembly of protein–polymer nano-conjugates into stimulus-responsive biomimetic protocells

X Huang, M Li, DC Green, DS Williams, AJ Patil… - Nature …, 2013 - nature.com
The mechanism of spontaneous assembly of microscale compartments is a central question
for the origin of life, and has technological repercussions in diverse areas such as materials …

Self-replication of DNA by its encoded proteins in liposome-based synthetic cells

P Van Nies, I Westerlaken, D Blanken, M Salas… - Nature …, 2018 - nature.com
Replication of DNA-encoded information and its conversion into functional proteins are
universal properties of life. In an effort toward the construction of a synthetic minimal cell, we …

The role of lipid membranes in life's origin

D Deamer - Life, 2017 - mdpi.com
At some point in early evolution, life became cellular. Assuming that this step was required
for the origin of life, there would necessarily be a pre-existing source of amphihilic …

Interfacing living and synthetic cells as an emerging frontier in synthetic biology

Y Elani - Angewandte Chemie, 2021 - Wiley Online Library
The construction of artificial cells from inanimate molecular building blocks is one of the
grand challenges of our time. In addition to being used as simplified cell models to decipher …