Emerging evidence for the widespread role of glutamatergic dysfunction in neuropsychiatric diseases

T McGrath, R Baskerville, M Rogero, L Castell - Nutrients, 2022 - mdpi.com
The monoamine model of depression has long formed the basis of drug development but
fails to explain treatment resistance or associations with stress or inflammation. Recent …

Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review

A Henning - Neuroimage, 2018 - Elsevier
Abstract Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …

FSL‐MRS: An end‐to‐end spectroscopy analysis package

WT Clarke, CJ Stagg, S Jbabdi - Magnetic resonance in …, 2021 - Wiley Online Library
Purpose We introduce FSL‐MRS, an end‐to‐end, modular, open‐source MRS analysis
toolbox. It provides spectroscopic data conversion, preprocessing, spectral simulation, fitting …

Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers

A Doose, FI Tam, I Hellerhoff, JA King, I Boehm… - Translational …, 2023 - nature.com
The acute state of anorexia nervosa (AN) is associated with widespread reductions in
cortical gray matter (GM) thickness and white matter (WM) volume, suspected changes in …

Cortical reorganization of the glutamate synapse in the activity‐based anorexia rat model: Impact on cognition

F Mottarlini, G Targa, G Bottan, B Tarenzi… - Journal of …, 2022 - Wiley Online Library
Patients suffering from anorexia nervosa (AN) display altered neural activity, morphological,
and functional connectivity in the fronto‐striatal circuit. In addition, hypoglutamatergic …

A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating …

H Steiger, L Booij, E Kahan, K McGregor, L Thaler… - Journal of Psychiatry and …, 2019 - jpn.ca
Background: This study explored state-related tendencies in DNA methylation in people with
anorexia nervosa. Methods: We measured genome-wide DNA methylation in 75 women …

Ketamine and zinc: treatment of anorexia nervosa via dual NMDA receptor modulation

JS Mitchell, DF Hermens, MR Bennett, AT Can… - CNS drugs, 2023 - Springer
Anorexia nervosa is a disorder associated with serious adverse health outcomes, for which
there is currently considerable treatment ineffectiveness. Characterised by restrictive eating …

Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior

ML Westwater, AG Murley, KMJ Diederen… - Translational …, 2022 - nature.com
Anorexia nervosa (AN) and bulimia nervosa (BN) are associated with altered brain structure
and function, as well as increased habitual behavior. This neurobehavioral profile may …

Anorexia nervosa, zinc deficiency and the glutamate system: The ketamine option

DF Hermens, G Simcock, M Dutton, AP Bouças… - Progress in Neuro …, 2020 - Elsevier
Anorexia nervosa (AN) is a severe, biological brain disorder with significant medical risks
and a tenacious development over time. Unfortunately, few treatments show efficacy in …

Ultra-high-field magnetic resonance spectroscopy in psychiatry

BR Godlewska, S Clare, PJ Cowen, UE Emir - Frontiers in psychiatry, 2017 - frontiersin.org
The advantages of ultra-high-field (UHF≥ 7T) MR have been demonstrated in a variety of
MR acquisition modalities. Magnetic resonance spectroscopy (MRS) can particularly benefit …