CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …

Summary The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of
over one million people worldwide. The causative agent, severe acute respiratory syndrome …

The ongoing COVID-19 pandemic has caused a global economic and health crisis. To
identify host factors essential for coronavirus infection, we performed genome-wide …

The autophagy protein ATG2, proposed to transfer bulk lipid from the endoplasmic reticulum
(ER) during autophagosome biogenesis, interacts with ER residents TMEM41B and VMP1 …

Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …