Osteoporosis is a common metabolic bone disease, influenced by genetic and
environmental factors, that increases bone fragility and fracture risk and, therefore, has a …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

Osteoblastic bone formation and osteoclastic bone resorption dynamically maintain the
bone homeostasis; in the present study, we attempt to investigate the mechanism of the …

Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The
homeostasis of bone is maintained by the balance between osteoblastic bone formation and …

In this study, for the first time we discovered that the M1/M2 macrophage phenotype ratio is
increased in bone marrow of ovariectomized (OVX) osteoporotic C57BL/6 mice. Considering …

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and
activity of different cell types in bone tissue. The discovery of miRNA actions and their targets …

Macrophages are found in all tissues and regulate tissue morphogenesis during
development through trophic and scavenger functions. The colony stimulating factor-1 (CSF …

The objective of this study is to design a graphene‐based miRNA transfection drug delivery
system for antiresorptive therapy. An efficient nonviral gene delivery system is developed …

Osteoimmunology research is a new emerging research field that investigates the links
between the bone and immune responses. Results from osteoimmunology studies suggest …

Bone remodeling is balanced by bone formation and bone resorption as well as by
alterations in the quantities and functions of seed cells, leading to either the maintenance or …