Chronic diseases are the leading cause of death worldwide with increasing prevalence in all
age groups, genders, and ethnicities. Most chronic disease deaths occur in middle-to low …

Diabetes mellitus (DM) is a metabolic disease that activates several molecular pathways
involved in neurodegenerative disorders. Metformin, an anti-hyperglycemic drug used for …

Evidence from clinical trials and observational studies suggests that both progressive
resistance exercise training (PRT) and metformin delay a variety of age-related morbidities …

Patient-centered communication (PCC) by healthcare professionals can contribute to
enacting and facilitating patients' self-management of chronic health conditions. This study …

This study is a randomized controlled clinical trial that verified the resistance training efficacy
on neuromuscular parameters, with muscle quality as primary outcome. Forty-four elderly …

Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised
metabolic health and psychological functioning worsen clinical outcomes, diminish quality of …

Background Due to the demographic ageing process and the increasing number of pre-frail
and frail individuals, new lifestyle interventions to enhance the quality of life (QoL) in …

Context The combination of two beneficial antidiabetes interventions, regular exercise and
pharmaceuticals, is intuitively appealing. However, metformin, the most commonly …

High-Fat-Diet (HFD)-induced obesity is a major contributor to heart and mobility premature
aging and mortality in both Drosophila and humans. The dSir2 genes are closely related to …

Aims To assess whether aerobic or resistance training has greater benefits in non-physically
active men with a long lasting type 1 diabetes. The effects of exercise were evaluated in …