Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

Communication between neurons in the brain occurs primarily through synapses made onto
elaborate treelike structures called dendrites. New electrical and optical recording …

The role of back-propagating dendritic action potentials in the induction of long-term
potentiation (LTP) was investigated in CA1 neurons by means of dendritic patch recordings …

The effect of the fluorescent Ca2+ indicator dye Fura-2 on Ca2+ dynamics was studied in
proximal apical dendrites of neocortical layer V and hippocampal CA1 pyramidal neurons in …

Under certain conditions, regenerative voltage spikes can be initiated locally in the dendrites
of CA1 pyramidal neurons. These are interesting events that could potentially provide …

THE dendrites of many types of neurons contain voltage-dependent Na+ and Ca2+
conductances that generate action potentials (see ref. 1 for review). The function of these …

Abstract Increases in postsynaptic [Ca 2+] i can result from Ca 2+ entry through ligand-gated
channels or voltage-gated Ca 2+ channels, or through release from intracellular stores. Most …

We investigated long-term potentiation (LTP) at mossy fiber synapses on CA3 pyramidal
neurons in the hippocampus. Using Ca 2+ imaging techniques, we show here that when …

Scientific models are abstractions that aim to explain natural phenomena. A successful
model shows how a complex phenomenon arises from relatively simple principles while …

1. We studied the effects of synaptic inhibition on backpropagating Na+ spikes in the apical
dendrites of CA1 pyramidal neurons in transverse slices from the rat hippocampus. Action …