The T‐cell receptor (TCR)–CD3 complex, expressed on T cells, determines the outcome of a
T‐cell response. It consists of the TCR‐αβ heterodimer and the non‐covalently associated …

T cells are master regulators of the immune response tuning, among others, B cells,
macrophages and NK cells. To exert their functions requiring high sensibility and specificity …

The analysis of T cell lipid raft proteome is challenging due to the highly dynamic nature of
rafts and the hydrophobic character of raft-resident proteins. We explored an innovative …

The increase in the prevalence of allergic diseases is believed to partially depend on
environmental changes. DNA methylation is a major epigenetic mechanism, which is known …

Ligand binding to the TCR causes a conformational change at the CD3 subunits to expose
the CD3ε cytoplasmic proline-rich sequence (PRS). It was suggested that the PRS is …

Signal transduction regulates the proper function of T cells in an immune response. Upon
binding to its specific ligand associated with major histocompatibility complex (MHC) …

Background The non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is
ubiquitously expressed in many types of cells. In T cells, the Nck1 isoform promotes T cell …

Following T‐cell antigen receptor (TCR) engagement, rearrangement of the actin
cytoskeleton supports intracellular signal transduction and T‐cell activation. The non …

FcεRI is a multi-subunit receptor found on the surface of mast cells and basophils.
Stimulation of this receptor can lead to release of histamine and other mediators that are …

The epidemiological features of allergic diseases vary between regions worldwide. Allergy
and immunological disorders in tropical Asia-Pacific region have special characteristics …