Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

INTRODUCTION The collective behavior of cells and insects often relies on self-organizing
processes. By releasing attractant signals, a few individuals can initiate the accumulation …

Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2-tdTomato mouse …

Classical dendritic cells (cDCs) form a critical interface between innate and adaptive
immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of …

Generation of tumor-infiltrating lymphocytes begins when tumor antigens reach the lymph
node (LN) to stimulate T cells, yet we know little of how tumor material is disseminated …

It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs)
upon leaving blood. Here we have shown that Ly-6C+ monocytes constitutively trafficked …

In eukaryotic cells, the nuclear envelope separates the genomic DNA from the cytoplasmic
space and regulates protein trafficking between the two compartments. This barrier is only …

Cell migration has two opposite faces: although necessary for physiological processes such
as immune responses, it can also have detrimental effects by enabling metastatic cells to …

Microglia phenotypes are highly regulated by the brain environment, but the transcriptional
networks that specify the maturation of human microglia are poorly understood. Here, we …