Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-
protein-coupled seven-span transmembrane receptors, are major regulators of cell …

In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic
stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory …

Stem cells reside in a specialized regulatory microenvironment or niche,, where they receive
appropriate support for maintaining self-renewal and multi-lineage differentiation capacity …

Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the
bone marrow. The stem cell niche is thought to provide signals that support key HSC …

Breast cancer is the most common cancer affecting women worldwide, with bone
metastases presenting as the most common site of disease recurrence. Bone metastases …

Objective Stromal cell–derived factor 1 (SDF‐1; CXCL12/pre–B cell growth‐stimulating
factor) is a dominant chemokine in bone marrow and is known to be involved in …

The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming
osteoblasts. These two cell types are fundamentally different in terms of progenitor cells …

The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …