Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Fibroblasts and macrophages are universal cell types across all mammalian tissues. These
cells differ in many ways including their cellular origins; dynamics of renewal, recruitment …

Gain-of-function (GOF) mutations in CXCR4 cause WHIM (warts, hypogammaglobulinemia,
infections, and myelokathexis) syndrome, characterized by infections, leukocyte retention in …

Knowledge about the hematopoietic niche has evolved considerably in recent years, in
particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity …

Mutation in the VEGF gene disturbs the production of chondrocytes and angiogenesis which
are essential for cartilage health. Cytokines and chemokines produced by auto-activation of …

Innate immune memory endows innate immune cells with antigen independent heightened
responsiveness to subsequent challenges. The durability of this response can be mediated …

Cellular competition for limiting hematopoietic factors is a physiologically regulated but
poorly understood process. Here, we studied this phenomenon by hampering hematopoietic …

Optogenetics is a versatile and powerful tool for the control and analysis of cellular signaling
processes. The activation of cellular receptors by light using optogenetic switches usually …

Recent evidence has indicated that interleukin 37 (IL-37) shows down-regulated expression
in patients with acute myeloid leukemia (AML), but its association with immunophenotypic …