Applications of the Morris water maze in the study of learning and memory

R D'Hooge, PP De Deyn - Brain research reviews, 2001 - Elsevier
The Morris water maze (MWM) was described 20 years ago as a device to investigate
spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the …

Spatial memory: Theoretical basis and comparative review on experimental methods in rodents

CM Paul, G Magda, S Abel - Behavioural brain research, 2009 - Elsevier
The assessment of learning and memory in animal models has been widely employed in
scientific research for a long time. Among these models, those representing diseases with …

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice

R Rola, J Raber, A Rizk, S Otsuka… - Experimental …, 2004 - Elsevier
Advances in the management of pediatric brain tumors have increased survival rates in
children, but their quality of life is impaired due to cognitive deficits that arise from irradiation …

Extreme sensitivity of adult neurogenesis to low doses of X-irradiation

S Mizumatsu, ML Monje, DR Morhardt, R Rola… - Cancer research, 2003 - AACR
Therapeutic irradiation of the brain is associated with a number of adverse effects, including
cognitive impairment. Although the pathogenesis of radiation-induced cognitive injury is …

[图书][B] Remembering the times of our lives: Memory in infancy and beyond

PJ Bauer - 2014 - taylorfrancis.com
The purpose of Remembering the Times of Our Lives: Memory in Infancy and Beyond is to
trace the development from infancy through adulthood in the capacity to form, retain, and …

[PDF][PDF] Hormones and the hippocampus

R Lathe - Journal of Endocrinology, 2001 - researchgate.net
Hippocampal lesions produce memory deficits, but the exact function of the hippocampus
remains obscure. Evidence is presented that its role in memory may be ancillary to …

X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats

E Tada, JM Parent, DH Lowenstein, JR Fike - Neuroscience, 2000 - Elsevier
The effects of X-irradiation on proliferating cells in the dentate subgranular zone were
assessed in young adult Fisher 344 rats exposed to a range of X-ray doses and followed for …

Development of the hippocampal formation from 2 to 42 years: MRI evidence of smaller area dentata in autism

O Saitoh, CM Karns, E Courchesne - Brain, 2001 - academic.oup.com
Autism, a neuropsychiatric disorder that severely impairs social, language and cognitive
development, has a clinical onset in the first years of life. Because components of the limbic …

Animal models of attention-deficit hyperactivity disorder

E Davids, K Zhang, FI Tarazi, RJ Baldessarini - Brain Research Reviews, 2003 - Elsevier
Attention-deficit hyperactivity disorder (ADHD) involves clinically heterogeneous
dysfunctions of sustained attention, with behavioral overactivity and impulsivity, of juvenile …

Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation

EM Yazlovitskaya, E Edwards, D Thotala, A Fu… - Cancer research, 2006 - AACR
Curative cancer treatment regimens often require cranial irradiation, resulting in lifelong
neurocognitive deficiency in cancer survivors. This deficiency is in part related to radiation …