Medication use in children represents 15–20% of total drug sales. More than 50% of
children receive at least one prescription medication a year. Despite this, few drugs have a …

Domain of unknown function (DUF) is a general term for many uncharacterized domains
with two distinct features: relatively conservative amino acid sequence and unknown …

A drug is granted a license for use after a thorough assessment of risks and benefits based
on high‐quality scientific proof of its efficacy and safety. Many drugs that are relevant to …

Objective: To systematically analyze the supporting evidence, drug information, and the type
of off-label drug use in recommendations on off-label drug use in pediatric guidelines …

Abstract Objective Antiseizure medications (ASMs) remain the mainstay of epilepsy
treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which …

Background: The COVID-19 pandemic has profoundly impacted the country's health
systems and diminished its capability to provide safe and effective healthcare. This article …

Developmental pharmacology describes the impact of maturation on drug disposition
(pharmacokinetics, PK) and drug effects (pharmacodynamics, PD) throughout the paediatric …

Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Off-label prescribing is widespread among pediatricians, and it is unlikely that this trend will
soon be bound by a uniform legal framework. This is necessitated by the fact that there are …

The limit for possible survival after extremely preterm birth has steadily improved and
consequently, more premature neonates with increasingly lower gestational age at birth now …