Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype

HL Vellers, SR Kleeberger, JT Lightfoot - Mammalian genome, 2018 - Springer
Exercise training which meets the recommendations set by the National Physical Activity
Guidelines ensues a multitude of health benefits towards the prevention and treatment of …

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

JJ Crowley, V Zhabotynsky, W Sun, S Huang… - Nature …, 2015 - nature.com
Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …

Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain

JD Perez, ND Rubinstein, DE Fernandez, SW Santoro… - elife, 2015 - elifesciences.org
The maternal and paternal genomes play different roles in mammalian brains as a result of
genomic imprinting, an epigenetic regulation leading to differential expression of the …

[PDF][PDF] Sex-specific dominance of gene expression in seed beetles

P Kaufmann, JL Rönn, E Immonen… - Molecular Biology and …, 2024 - academic.oup.com
When different alleles are favored in different environments, dominance reversal where
alternate alleles are dominant in the environment in which they are favored can generate net …

Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions

CA Edwards, WMD Watkinson, SB Telerman… - Elife, 2023 - elifesciences.org
In mouse and human, genes subjected to genomic imprinting have been shown to function
in development, behavior, and post-natal adaptations. Failure to correctly imprint genes in …

A compendium of methods: Searching allele specific expression via RNA sequencing

S Asthana, HN Yadav, N Sharma, VK Singh - Gene, 2024 - Elsevier
Diploid mammalian genome has paired alleles for each gene; typically allowing for equal
expression of the two alleles within the cell/tissue. However, genetic regulatory elements …

Buffering of Genetic Regulatory Networks in Drosophila melanogaster

JM Fear, LG León-Novelo, AM Morse, AR Gerken… - Genetics, 2016 - academic.oup.com
Regulatory variation in gene expression can be described by cis-and trans-genetic
components. Here we used RNA-seq data from a population panel of Drosophila …

Inheritance patterns of the transcriptome in hybrid chickens and their parents revealed by expression analysis

H Gu, X Qi, Y Jia, Z Zhang, C Nie, X Li, J Li, Z Jiang… - Scientific reports, 2019 - nature.com
Although many phenotypic traits of chickens have been well documented, the genetic
patterns of gene expression levels in chickens remain to be determined. In the present …

Replicate sequencing libraries are important for quantification of allelic imbalance

A Mendelevich, S Vinogradova, S Gupta… - Nature …, 2021 - nature.com
A sensitive approach to quantitative analysis of transcriptional regulation in diploid
organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near …

A Generalized Linear Model for Decomposing Cis-regulatory, Parent-of-Origin, and Maternal Effects on Allele-Specific Gene Expression

Y Takada, R Miyagi, A Takahashi… - G3: Genes, Genomes …, 2017 - academic.oup.com
Joint quantification of genetic and epigenetic effects on gene expression is important for
understanding the establishment of complex gene regulation systems in living organisms. In …