Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

In fleshy fruits, organic acids are the main source of fruit acidity and play an important role in
regulating osmotic pressure, pH homeostasis, stress resistance, and fruit quality. The …

As a self‐degrading and highly conserved survival mechanism, autophagy plays an
important role in maintaining cell survival and recycling. The discovery of autophagy‐related …

The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved
phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it …

The natural lignan diphyllin has shown promising antitumor activity, although its clinical
advancement has been impeded by challenges such as low solubility, poor metabolic …

Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC)
niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC …

Proper balance of exocytosis and endocytosis is important for the maintenance of plasma
membrane lipid and protein homeostasis. This is especially critical in human podocytes and …

Proper balance of exocytosis and endocytosis is important for the maintenance of plasma
membrane lipid and protein homeostasis. This is especially critical in human podocytes and …

Glioblastoma (GB) is the most frequent malignant brain tumor among adults and currently
there is no effective treatment. This aggressive tumor grows fast and spreads through the …

The insulin receptor (InR) is a central regulator of metabolism, growth, and proliferation in
both humans and Drosophila. Integrating a range of signals, InR coordinates pleiotropic …