Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important
products that exhibit various biological properties (eg, cytotoxic, insecticidal, antifungal …

Podophyllotoxin (PTOX) is a biologically active compound derived from the podophyllum
plant, and both it and its derivatives possess excellent antitumor activity. The PTOX …

The aryltetralin-type lignan podophyllotoxin, the main agent present in the resin extracted
from the rhizomes of different podophyllum species, possesses important antineoplastic and …

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using
microwave-assisted three-component reactions is reported in this study. Novel …

The comprehensive review contains the analysis of literature data concerning reactions of
heterocyclization of aminoazoles and demonstrates the application of these types of …

The synthesized nine aza-podophyllotoxin derivatives (8a–f, 10, 12 and 14) have been
evaluated for their cytotoxicity in a panel of tumor cancer cell lines (Zr-75-1, MCF7, KB …

A new series of resveratrol analogues was designed, synthesized, and demonstrated to be
tubulin polymerization inhibitors. Most of these compounds exhibited antiproliferative activity …

Our previous study found that 2-phenyl-4-quinolone (2-PQ) derivatives are antimitotic
agents, and we adopted the drug design concept of scaffold hopping to replace the 2 …

Chemical inhibition of epigenetic regulatory proteins BrdT and Brd4 is emerging as a
promising therapeutic strategy in contraception, cancer, and heart disease. We report an …

A series of novel naphthoquinone-fused podophyllotoxins containing fluoro and
trifluoromethyl substituents were synthesized in a medium with good yields using two …